1.Smoliga, J.M., Bost, J. and Maroon, J.C., Potential Benefits of Resveratrol Supplementation for Optimizing Health and Preventing Chronic Disease. Antiaging Therapeutics, 11.
2.Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochemical Pharmacology.2006;72:1439-1452.
3.Howitz K, Sinclair D. Xenohormesis: Sensing the Chemical Cues of Other Species. Cell.2008;133:387-391.
4.Howitz, K. T. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiaelifespan. Nature 425, 191–196 (2003).
5.Lamming, D. W., Wood, J. G. & Sinclair, D. A. Small molecules that regulate lifespan: evidence for xenohormesis. Mol. Microbiol. 53, 1003–1009 (2004).
6.Sinclair, D. A. & Howitz, K. T. in Handbook of the Biology of Aging (eds Masoro, E. J. & Austad, S. N.) 63–104 (Elsevier, Boston, 2006
7.Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews.2006;5:493-506.
8.Renaud S, deLorgeril M. Wine, alocohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992;339:1523-1526.
9.Nanji AA, French SW. Alcoholic beverages and coronary heart disease. Atherosclerosis.1986;60:197-198.
10.Siemann, E. H. & Creasy, L. L. Concentration of the phytoalexin resveratrol in wine. Am. J. Eno. Vitic. 43, 49–52 (1992).
11.Bielsalski HK. Polyphenols and inflammation: basic interactions. Current opinion in clinical nutrition and metabolic care. 2007;10:724-728.
12.Baur JA, Pearson KJ, Price NL, et al. resveratrol improves health and survival of mice on a highcalorie diet. Nature. 2006;444:337-342
13.Das S, Das DK. Anti-inflammatory responses of resveratrol. Inflammation & Allergy – Drug Targets. 2007;6:168-173.
14.Jang, M. et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218–220 (1997).
15.Bradamante, S., Barenghi, L. & Villa, A. Cardiovascular protective effects of resveratrol.Cardiovasc. Drug Rev. 22, 169–188 (2004).
16.Robb EL, Page MM, Wiens BE, Stuart JA. Molecular mechanisms of oxidative stress resistance induced by resveratrol: specific and progressive induction of MnSOD. Biochemical and Biophysical Research Communications.2008;367:406-412.
17.Lagouge M, Argmann C, Gerhart-Hines Z, et al. resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell.2006;127:1109-1122.
18.Houten SM, Auwerx J. PGC-1α: Turbocharing mitochondria. Cell. 2004;119:5-7.
19.Bost J, Smoliga JM, Bost KM, Maroon JC. Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults. Paper presented at: American College of Sports Medicine Annual Meeting; May 28-31, 2008; Indianapolis, IN.
20.Smoliga JM, Bost J, Bost KM, Maroon JC. Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults. Paper presented at: Mid-Atlantic Regional Chapter of the AmericanCollege of Sports Medicine; November 2-3, 2007; Harrisburg, PA
21.Kramer HF, Goodyear LJ. Exercise, MAPK, and NF-κB signaling in skeletal muscle. Journal of Applied Physiology. 2007;103:388-395.
22.Schreiber L, McAnulty S, McAnulty L, et al. resveratrol and catechin administration blunts exerciseinduced oxidative stress and cytokine IL-8. Paper presented at: American College of Sports Medicine Annual Meeting; May 28-31, 2008, 2008; Indianapolis, IN.
23.Elmali, N. et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm. Res. 54, 158–162 (2005).
24.Gronbaek, M. et al. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ310, 1165–1169 (1995).
25.Bohm, M., Rosenkranz, S. & Laufs, U. Alcohol and red wine: impact on cardiovascular risk.Nephrol. Dial. Transplant. 19, 11–16 (2004).
26.Seigneur, M. et al. Effect of the consumption of alcohol, white wine, and red wine on platelet function and serum lipids. J. Appl. Cardiol. 5, 215–222 (1990).
27.Demrow, H. S., Slane, P. R. & Folts, J. D. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91, 1182–1188 (1995).
28.Wang, Z. et al. Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels. Int. J. Mol. Med. 16, 533–540 (2005).
29.Fitzpatrick, D. F., Hirschfield, S. L. & Coffey, R. G. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol. 265, H774–H778 (1993)
30.Lekakis, J. et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur. J. Cardiovasc. Prev. Rehabil. 12, 596–600 (2005).
31.Szewczuk, L. M., Forti, L., Stivala, L. A. & Penning, T. M. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J. Biol. Chem. 279, 22727–22737 (2004)
32.Li, H. F., Chen, S. A. & Wu, S. N. Evidence for the stimulatory effect of resveratrol on Ca2+-activated K+ current in vascular endothelial cells.Cardiovasc. Res. 45, 1035–1045 (2000).
33.Orallo, F. et al. The possible implication oftransresveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol. Pharmacol. 61, 294–302 (2002).
Anekonda TS. resveratrol – a boon for treating Alzheimer’s disease? Brain Research Reviews.2006;52:316-326.
34.Anekonda TS. resveratrol – a boon for treating Alzheimer’s disease? Brain Research Reviews. 2006;52:316-326.
35.Chen, Y., Tseng, S. H., Lai, H. S. & Chen, W. J. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery 136, 57–66 (2004).
36.Oshima, M. et al. Suppression of intestinal polyposis in Apcδ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803–809 (1996).
37.Zha, S., Yegnasubramanian, V., Nelson, W. G., Isaacs, W. B. & De Marzo, A. M. Cyclooxygenases in cancer: progress and perspective. Cancer Lett.215, 1–20 (2004).
38.Khanduja, K. L., Bhardwaj, A. & Kaushik, G. Resveratrol inhibits N-nitrosodiethylamine-induced ornithine decarboxylase and cyclooxygenase in mice. J. Nutr. Sci. Vitaminol. (Tokyo) 50, 61–65 (2004).
39.Li, Z. G. et al. Suppression of N-nitro somethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 23, 1531–1536 (2002).
40.Aziz, M., Afaq, F. & Ahmad, N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem. Photobiol. 81, 25–31 (2004).
41.Kimura, Y. & Okuda, H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 131, 1844–1849 (2001).
42.Tseng, S. H. et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin. Cancer Res. 10, 2190–2202 (2004).
43.Aggarwal, B. B. et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24, 2783–2840(2004).
44.Guarente, L. & Picard, F. Calorie restriction — the SIR2 connection. Cell 120, 473–482 (2005).
45.Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999).
46.Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan inCaenorhabditis elegans. Nature 410, 227–230 (2001).
47.Rogina, B. & Helfand, S. L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl Acad. Sci. USA 101, 15998–16003 (2004).
48.Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature.2003;425:191-196.
49.Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mechanisms of Ageing and Development. 2005;126:987-1002.
50.Valenzano, D. R. et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a shortlived vertebrate. Curr. Biol. 16, 296–300 (2006).
51.Alcendor RR, Gao S, Zhai P, et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation Research. 2007;100:1512-1521
52.Boocock DJ, Faust GES, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemoprotective agent. Cancer Epidemiology, Biomarkers & Prevention.2007;16:1246-1252
53.Smoliga JM, Bost J, Bost KM, Maroon JC. Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults. Paper presented at: Mid-Atlantic Regional Chapter of the American College of Sports Medicine; November 2-3, 2007; Harrisburg, PA.